Solubility Enhancement of Poorly Soluble Drug Ezetimibe by Developing Self Nano Emulsifying Drug Delivery System

Objectives: To enhance solubility, dissolution, and permeability of poorly water-soluble drug Ezetimibe (EZE) using a self-nano emulsifying delivery system (SNEDDS). Methods: Initially, the solubility EZE was determined in various oils buffers. Surfactants co-surfactants were screened based on oil as per emulsification efficacy test. Liquid SNEDDS developed characterized. Solid characterized optimized liquid followed by development EZE-loaded Tablet SNEDDS. Finding: (LSNEDDS) formulated Capmul MCM C8 EP, Cremophore RH 40, Labrafil M 2125 CS oil, surfactant, co-surfactant respectively. Optimized L-SNEDDS formulation found to be efficient with an average %T 99.5%, content 98.43%, flask inversion 0 numbers, particle size 36.7 nm, zeta potential -57.5 mV, Polydispersibility index 0.119. Also, vitro release profile from encapsulated hard gelatin capsules evaluated different dissolution media viz. simulated gastric fluid intestinal fluid. For drug, more than 95% cumulative observed within 30 min exclusive pH medium. The adsorbed solid support then mixed tablet blends compressed into tablets. Further, no adverse changes globule size, shape, SNEDDS, apparent conversion powder form form. Novelty: showed enhanced comparison pure drugs. Conversion PSNEDDS would novel approach overcome limitations associatedwith dosage forms. Keywords: (EZE); Selfnano (SNEDDS); (L SNEDDS); (PSNEDDS); (TSNEDDS)